Using previous version’s profile: It might possible to get this problem in case if you are using Outlook profile previously created in older Outlook version.I recently setup a Windows 10 machine to replace an older computer at the office. ost were accidently deleted or damaged, then you can face this type of problem Missing Outlook data file: In case if Outlook data file like. Compatibility Mode: This issue might occurs if Outlook is running in the Compatibility Mode. Corrupted Navigation Pane: It might possible to get this error if “profilename.xml” file is corrupted. The file XXXXXXX.pst canot be opened” Reasons behind “cannot open Microsoft Outlook” issue They explained that “cannot open Outlook” error appears on the screen in order to click on Outlook’s icon and as result of it, they can’t access or open outlook App on your Windows device. Many Outlook users reported about this problem on various online platforms including Microsoft Official online forum site and other popular platforms, and asked for the solution. To check if the file is corrupted or not, check the size of “profilename.xml” file is 0 KB. 
According to Microsoft, the major cause of “cannot start Microsoft Outlook” problem is a corrupted Navigation Pane Setting file i.e., “profilename.xml” where “profilename” is the name of your Microsoft Outlook profile. This problem is usually occurs on Outlook 2007, 2010, 2013 and Outlook 2016 that it seems to manifest regardless of your Windows version including Windows 10/8.1/8/7 Operating System.
It is common error that is categorised as Microsoft Outlook error. What is “cannot open Microsoft Outlook” error? Here, we are discussing about “cannot start Microsoft Outlook” issue in details and providing some recommended methods/procedures to fix. Cannot open the Outlook Window” error while trying to open Outlook App on your computer, then you can follow our instructions to fix this problem.
If you are facing “ Cannot start Microsoft Outlook.
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